abstract：PURPOSE:Bone marrow adherent cells contain conventional bone marrow stromal cells and mesenchymal stem cells and these cells constitute the hematopoietic microenvironment. Mesenchymal stem cells have the capacity to give rise to multiple mesenchymal lineage cells and even ectodermal lineage cells. In the present study,...

journal_title：Journal of cancer research and clinical oncology

authors： Li Q,Hisha H,Takaki T,Adachi Y,Li M,Song C,Feng W,Okazaki S,Mizokami T,Kato J,Inaba M,Hosaka N,Maki M,Ikehara S

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Long-term human papillomavirus (HPV) infection is a prerequisite for cervical cancer. IL-1beta and IL-1Ra expression levels play an important role in cervical carcinogenesis. Several functional genetic variants in IL1B and IL-RN have been reported to be associated with IL-1beta expression and cancer susceptibil...

journal_title：Journal of cancer research and clinical oncology

authors： Qian N,Chen X,Han S,Qiang F,Jin G,Zhou X,Dong J,Wang X,Shen H,Hu Z

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Recently, it was reported that expression of transglutaminase 2 plays an important role in doxorubicin/cisplatin resistance in breast and ovarian cancer. The aims of this study were to verify the role of transglutaminase 2 in cisplatin response in non-small cell lung cancer (NSCLC) and to study if transglutamin...

journal_title：Journal of cancer research and clinical oncology

authors： Park KS,Kim HK,Lee JH,Choi YB,Park SY,Yang SH,Kim SY,Hong KM

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:We have demonstrated that overexpression of osteopontin (OPN) could contribute to metastasis in hepatocellular carcinoma (HCC), and that OPN-positive cancer cells are often localized in the periphery of cancer nodules adjacent to stromal cells. This study was to identify the difference of intratumor genomic abe...

journal_title：Journal of cancer research and clinical oncology

authors： Wu JC,Sun BS,Ren N,Ye QH,Qin LX

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:In advanced ovarian cancers (OCs), p53 mutations are frequently observed. The objective of this study was to explore the value of the p53 mutational status, using four different techniques, in advanced OC patients as a predictive marker for responsiveness to platinum-based chemotherapy. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Bauerschlag DO,Schem C,Weigel MT,Von Kaisenberg C,Strauss A,Bauknecht T,Maass N,Meinhold-Heerlein I

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:In this study, we applied laser capture microdissection and a proteomic approach to identify novel nasopharyngeal carcinoma (NPC) biomarkers. METHODS:Proteins from pooled microdissected NPC and normal nasopharyngeal epithelial tissues (NNET) were separated by two-dimensional gel electrophoresis, and differenti...

journal_title：Journal of cancer research and clinical oncology

authors： Li XM,Huang WG,Yi H,Cheng AL,Xiao ZQ

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize changes in the expression of copper-zinc superoxide dismutase (Cu/Zn-SOD) and manganese SOD (Mn-SOD) in oral squamous-cell carcinoma (OSCC). METHODS:Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of Cu/Zn-SOD and Mn-SOD mRNA express...

journal_title：Journal of cancer research and clinical oncology

authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The present study was undertaken to examine the amplification and expression status of Cks1 in breast cancer and its significance. METHODS:The amplification and expression status of Cks1 gene was examined by FISH, real-time PCR and immunohistochemistry, respectively. RNA interference was used to detect the eff...

journal_title：Journal of cancer research and clinical oncology

authors： Wang XC,Tian LL,Tian J,Wu HL,Meng AM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

journal_title：Journal of cancer research and clinical oncology

authors： Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

更新日期：2009-09-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：AIMS:With three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In this study, we attempted to identify the potential interaction of DYX1C1 and heat shoc...

journal_title：Journal of cancer research and clinical oncology

authors： Chen Y,Zhao M,Wang S,Chen J,Wang Y,Cao Q,Zhou W,Liu J,Xu Z,Tong G,Li J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:This study was to investigate whether the topoisomerase (Top) I inhibitor topotecan and the Top II inhibitor etoposide could modulate the hypoxia-induced HIF-1alpha expression in non-small cell lung cancer (NSCLC) cell lines. METHODS:Hypoxic conditions were maintained in a humidified airtight anaerobic incubat...

journal_title：Journal of cancer research and clinical oncology

authors： Choi YJ,Rho JK,Lee SJ,Jang WS,Lee SS,Kim CH,Lee JC

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Endometrial adenocarcinoma, due to a frequent activation of PI3 K/AKT has been proposed as a candidate neoplasm for the treatment with mTOR inhibitors. Yet, data on the expression of mTOR cascade components in endometrial cancer are lacking. METHODS:To provide a basis for futher studies with mTOR inhibitors, w...

journal_title：Journal of cancer research and clinical oncology

authors： Darb-Esfahani S,Faggad A,Noske A,Weichert W,Buckendahl AC,Müller B,Budczies J,Röske A,Dietel M,Denkert C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:The spread of malignant lymph nodes due to malignancies of the head and neck is systematically observed. However, sentinel lymph nodes in the cervical region, such as in the axillary or supraclavicular regions, are not described. Therefore, precise preoperative lymph node screening of all neck compartments is r...

journal_title：Journal of cancer research and clinical oncology

authors： Hohlweg-Majert B,Metzger MC,Voss PJ,Hölzle F,Wolff KD,Schulze D

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and development. The purpose of this study was to examine the involvement of stat...

journal_title：Journal of cancer research and clinical oncology

authors： Xi W,Rui W,Fang L,Ke D,Ping G,Hui-Zhong Z

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular path...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto H,Tobo T,Nakamori M,Imamura M,Kojima A,Oda Y,Nakamura N,Takahira T,Yao T,Tsuneyoshi M

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of leukocytes to the site of inflammation. Tumor invasion and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. In this study, we aimed to assess the role of CCR1...

journal_title：Journal of cancer research and clinical oncology

authors： Wang CL,Sun BS,Tang Y,Zhuang HQ,Cao WZ

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:We investigated the possible association of DNA polymorphisms -2548G/A and Q223R in the leptin (LEP) and leptin receptor (LEPR) genes, respectively, which both affect the amount of circulating cytokine-type hormone leptin, with risk for development of oral cancer. METHODS:Polymerase chain reaction-based restri...

journal_title：Journal of cancer research and clinical oncology

authors： Yapijakis C,Kechagiadakis M,Nkenke E,Serefoglou Z,Avgoustidis D,Vylliotis A,Perrea D,Neukam FW,Patsouris E,Vairaktaris E

更新日期：2009-04-01 00:00:00

abstract：:The role of different cytogenetic changes has been extensively evaluated in patients with acute myeloid leukemia (AML), and cytogenetic analysis of AML blasts is essential to form prognostic subgroups in order to stratify for the extent of therapy. Nevertheless, 40-45% of AML patients lack such cytogenetic markers, i....

journal_title：Journal of cancer research and clinical oncology

authors： Scholl S,Fricke HJ,Sayer HG,Höffken K

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age. As we have previously reported, stem-cell grafts regularly contain quantities of plasma c...

journal_title：Journal of cancer research and clinical oncology

authors： Kopp HG,Yildirim S,Weisel KC,Kanz L,Vogel W

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Two large, randomized, placebo-controlled trials (IRESSA NSCLC Trial Assessing Combination Therapy; INTACT 1 and 2) in non-small-cell lung cancer (NSCLC) failed to show survival benefit for gefitinib (IRESSA) in combination with first-line platinum-based chemotherapy. Epidermal growth factor receptor (EGFR) sta...

journal_title：Journal of cancer research and clinical oncology

authors： Giaccone G,Iacona RB,Fandi A,Janas M,Ochs JS,Herbst RS,Johnson DH

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To investigate the relationship between microvessel density, expression of vascular endothelial growth factor A (VEGF-A) and micrometastases in peripheral blood of patients with breast cancer. METHOD:Microvessel density (MVD) and expression of VEGF-A were detected by immunohistochemistry S-P. Nested RT-PCR was...

journal_title：Journal of cancer research and clinical oncology

authors： Xie XD,Qu SX,Liu ZZ,Zhang F,Zheng ZD

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS:VEGF was measured using ELISA in the largest patient group (n = 167) to date. RESULTS:Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tum...

journal_title：Journal of cancer research and clinical oncology

authors： Zusterzeel PL,Span PN,Dijksterhuis MG,Thomas CM,Sweep FC,Massuger LF

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Survivin, an inhibitor of apoptosis protein and a cell cycle regulator, has been detected in the majority of human cancers. Five splice variants (survivin, survivin-2alpha, survivin-2B, survivin-3B, and survivin-DeltaEx3) have been identified; their expressions have been investigated here. METHODS:By means of ...

journal_title：Journal of cancer research and clinical oncology

authors： De Maria S,Pannone G,Bufo P,Santoro A,Serpico R,Metafora S,Rubini C,Pasquali D,Papagerakis SM,Staibano S,De Rosa G,Farina E,Emanuelli M,Santarelli A,Mariggiò MA,Lo Russo L,Lo Muzio L

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Our goal was to prospectively evaluate self-reported quality-of-life (QoL) during second-line therapy in 51 consecutive patients with cytokine-refractory kidney cancer treated with sorafenib or sunitinib. METHODS:QoL was assessed by the EORTC QoL questionnaire QLQ-C30 at baseline and at weeks 4, 6, 10, 12 and ...

journal_title：Journal of cancer research and clinical oncology

authors： Herrmann E,Gerss J,Bierer S,Köpke T,Bolenz C,Hertle L,Wülfing C

更新日期：2009-01-01 00:00:00

abstract：:Gastric cancer is a major health issue and a leading cause of death worldwide. The results of standard therapy remain unsatisfactory mainly because of diagnosis at the late stage of disease. Innovative strategies such as neoadjuvant chemotherapy in locally advanced cancer have improved the outcome even in operable cas...

journal_title：Journal of cancer research and clinical oncology

authors： Menges M,Hoehler T

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-alpha and PDGFR-beta. Investigations were performed to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation and apoptosis induction were measured with and wi...

journal_title：Journal of cancer research and clinical oncology

authors： Mundhenke C,Weigel MT,Sturner KH,Roesel F,Meinhold-Heerlein I,Bauerschlag DO,Schem C,Hilpert F,Jonat W,Maass N

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To explore the appropriate method of mediastinal lymph node dissection for selected clinical stage IA (cIA) non-small cell lung cancer (NSCLC). METHODS:From 1998 through 2002, the curative-intent surgery was performed to 105 patients with cIA NSCLC who had been postoperatively identified as pathologic-stage T1...

journal_title：Journal of cancer research and clinical oncology

authors： Ma K,Chang D,He B,Gong M,Tian F,Hu X,Ji Z,Wang T

更新日期：2008-12-01 00:00:00

abstract：PURPOSE AND METHODS:Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome ...

journal_title：Journal of cancer research and clinical oncology

authors： Pehlivan D,Gunduz E,Gunduz M,Nagatsuka H,Beder LB,Cengiz B,Rivera RS,Fukushima K,Palanduz S,Ozturk S,Yamanaka N,Shimizu K

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Bone morphogenetic proteins (BMPs) are multifunctional regulators of various cell functions. The BMP-signalling network plays a pivotal role during embryogenesis and tumorigenesis. BMPs, e.g. BMP-2 exert their biological function in a time and concentration-dependent manner but also modulated by the context of ...

journal_title：Journal of cancer research and clinical oncology

authors： Steinert S,Kroll TC,Taubert I,Pusch L,Hortschansky P,Höffken K,Wölfl S,Clement JH

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

journal_title：Journal of cancer research and clinical oncology

authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to correlate chemotherapy-induced nausea and vomiting (CINV) with commonly occurring single nucleotide polymorphisms (SNP) in the 5-hydroxytryptamine receptor 3 genes (HTR3). Women with breast cancer without previous chemotherapy were eligible for this prospective study. All patients received...

journal_title：Journal of cancer research and clinical oncology

authors： Fasching PA,Kollmannsberger B,Strissel PL,Niesler B,Engel J,Kreis H,Lux MP,Weihbrecht S,Lausen B,Bani MR,Beckmann MW,Strick R

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study. PATIENTS AND METHODS:The mean age was 33.3 years with a female-to-male ratio of 1.2 : 1. ...

journal_title：Journal of cancer research and clinical oncology

authors： Balke M,Schremper L,Gebert C,Ahrens H,Streitbuerger A,Koehler G,Hardes J,Gosheger G

更新日期：2008-09-01 00:00:00